Acute and subacute toxicity of Solanum aethiopicum Linn Gilo (Solanaceae) aqueous leaves extract in Wistar rats

The aims of this study was to evaluate the acute and sub-acute toxicity Solanum aethiopicum Linn Gilo aqueous leaves extract in Wistar rats. Female rats received a single dose (2000, 3000, 4000 5000 mg/kg/ bw) for toxicity. Both, male female 300,500 800 bw during 21 days measurements. Blood sample collected determination some haematological, biochemical oxidative stress parameters. Besides, histological sections liver, heart, lungs kidneys were analyzed. Results showed that lethal greater than 5000mg/kg. did not alter haematological It maintained blood sugar proteinuria within normal limits had good antioxidant activity. histopathological analysis revealed architecture lung, kidney, heart liver. LINN GILO at doses 300,500,800mg/kg/bw has therefore shown any sign